[HTML][HTML] E-Selectin mediates pathogenic effects of antiphospholipid antibodies
RG Espinola, X Liu, M Colden-Stanfield, J Hall… - Journal of Thrombosis …, 2003 - Elsevier
Antiphospholipid (aPL) antibodies, detected in patients with antiphospholipid syndrome
(APS) are associated with thrombosis, pregnancy loss and thrombocytopenia. Studies have
shown that aPL are thrombogenic in vivo, but the mechanism (s) involved are not completely
understood. Several studies have demonstrated that aPL antibodies activate endothelial
cells (ECs) in vitro, as determined by up-regulation of adhesion molecules: E-selectin (E-
sel); intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 …
(APS) are associated with thrombosis, pregnancy loss and thrombocytopenia. Studies have
shown that aPL are thrombogenic in vivo, but the mechanism (s) involved are not completely
understood. Several studies have demonstrated that aPL antibodies activate endothelial
cells (ECs) in vitro, as determined by up-regulation of adhesion molecules: E-selectin (E-
sel); intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 …
