Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies
SS Pierangeli, ME Vega-Ostertag, E Raschi… - Annals of the rheumatic …, 2007 - Elsevier
Objective: A study was undertaken to investigate the in vivo pathogenic role of Toll-like
receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying the thrombogenic
antiphospholipid (aPL) activity in lipopolysaccharide (LPS) non-responsive (LPS–/–) mice
and the association between tlr4 gene polymorphisms and APS in patients. Methods: IgGs
from two patients with APS, one with aPL negative systemic lupus erythematosus (SLE) and
one with normal human serum (NHS), were evaluated for thrombosis, tissue factor (TF) …
receptor 4 (TLR-4) in the antiphospholipid syndrome (APS) by studying the thrombogenic
antiphospholipid (aPL) activity in lipopolysaccharide (LPS) non-responsive (LPS–/–) mice
and the association between tlr4 gene polymorphisms and APS in patients. Methods: IgGs
from two patients with APS, one with aPL negative systemic lupus erythematosus (SLE) and
one with normal human serum (NHS), were evaluated for thrombosis, tissue factor (TF) …
