[HTML][HTML] AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
D Luo, Y He, H Zhang, L Yu, H Chen, Z Xu… - Journal of Biological …, 2008 - ASBMB
We have previously shown that ASK1-interacting protein 1 (AIP1) transduces tumor necrosis
factor-induced ASK1-JNK signaling. Because endoplasmic reticulum (ER) stress activates
ASK1-JNK signaling cascade, we investigated the role of AIP1 in ER stress-induced
signaling. We created AIP1-deficient mice (AIP1-KO) from which mouse embryonic
fibroblasts and vascular endothelial cells were isolated. AIP1-KO cells show dramatic
reductions in ER stress-induced, but not oxidative stress-induced, ASK1-JNK activation and …
factor-induced ASK1-JNK signaling. Because endoplasmic reticulum (ER) stress activates
ASK1-JNK signaling cascade, we investigated the role of AIP1 in ER stress-induced
signaling. We created AIP1-deficient mice (AIP1-KO) from which mouse embryonic
fibroblasts and vascular endothelial cells were isolated. AIP1-KO cells show dramatic
reductions in ER stress-induced, but not oxidative stress-induced, ASK1-JNK activation and …