JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1
L Yu, W Min, Y He, L Qin, H Zhang, AM Bennett… - Journal of Biological …, 2009 - jbc.org
Previously we have shown that tyrosine 718 of ASK1 when phosphorylated is critical for
SOCS1 binding and SOCS1-mediated degradation of ASK1. However, the kinase and
phosphatase responsible for phosphorylation and dephosphorylation of ASK1 at Tyr-718
are unknown. In this study, we identified JAK2 and SHP2 as a Tyr-718-specific kinase and
phosphatase, respectively. Interferon-γ (IFN-γ) induced degradation of ASK1 in normal but
not in SOCS1-KO endothelial cells (EC). IFN-γ-induced tyrosine phosphorylation of ASK1 at …
SOCS1 binding and SOCS1-mediated degradation of ASK1. However, the kinase and
phosphatase responsible for phosphorylation and dephosphorylation of ASK1 at Tyr-718
are unknown. In this study, we identified JAK2 and SHP2 as a Tyr-718-specific kinase and
phosphatase, respectively. Interferon-γ (IFN-γ) induced degradation of ASK1 in normal but
not in SOCS1-KO endothelial cells (EC). IFN-γ-induced tyrosine phosphorylation of ASK1 at …
