[HTML][HTML] Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and-independent pathways in …
TH Wang, DM Popp, HS Wang, M Saitoh… - Journal of Biological …, 1999 - ASBMB
The antineoplastic agent paclitaxel (Taxol TM), a microtubule stabilizing agent, is known to
arrest cells at the G 2/M phase of the cell cycle and induce apoptosis. We and others have
recently demonstrated that paclitaxel also activates the c-Jun N-terminal kinase/stress-
activated protein kinase (JNK/SAPK) signal transduction pathway in various human cell
types, however, no clear role has been established for JNK/SAPK in paclitaxel-induced
apoptosis. To further examine the role of JNK/SAPK signaling cascades in apoptosis …
arrest cells at the G 2/M phase of the cell cycle and induce apoptosis. We and others have
recently demonstrated that paclitaxel also activates the c-Jun N-terminal kinase/stress-
activated protein kinase (JNK/SAPK) signal transduction pathway in various human cell
types, however, no clear role has been established for JNK/SAPK in paclitaxel-induced
apoptosis. To further examine the role of JNK/SAPK signaling cascades in apoptosis …