Mechanisms of endothelial dysfunction, injury, and death
JS Pober, W Min, JR Bradley - Annual Review of Pathology …, 2009 - annualreviews.org
Vascular endothelial cells normally perform several key homeostatic functions such as
keeping blood fluid, regulating blood flow, regulating macromolecule and fluid exchange
with the tissues, preventing leukocyte activation, and aiding in immune surveillance for
pathogens. Injury or cell death impairs or prevents conduct of these activities, resulting in
dysfunction. Most endothelial cell death is apoptotic, involving activation of caspases, but
nonapoptotic death responses also have been described. Stimuli that can cause endothelial …
keeping blood fluid, regulating blood flow, regulating macromolecule and fluid exchange
with the tissues, preventing leukocyte activation, and aiding in immune surveillance for
pathogens. Injury or cell death impairs or prevents conduct of these activities, resulting in
dysfunction. Most endothelial cell death is apoptotic, involving activation of caspases, but
nonapoptotic death responses also have been described. Stimuli that can cause endothelial …
