[HTML][HTML] Isolation and characterisation of potential respiratory syncytial virus receptor (s) on epithelial cells
R Malhotra, M Ward, H Bright, R Priest, MR Foster… - Microbes and …, 2003 - Elsevier
Respiratory syncytial virus (RSV) infection causes severe lower respiratory diseases in
infancy, early childhood and the elderly. RSV infections respond poorly to current therapies.
Therefore, we initiated a search for novel drug targets by investigating the characteristics
and identity of RSV adhesion receptors on mammalian cells. Soluble human lectins,
complex polysaccharides and a low molecular selectin antagonist, TBC1269, were used to
characterise and isolate the RSV receptor on a human epithelial cell line (Hep2 cells). The …
infancy, early childhood and the elderly. RSV infections respond poorly to current therapies.
Therefore, we initiated a search for novel drug targets by investigating the characteristics
and identity of RSV adhesion receptors on mammalian cells. Soluble human lectins,
complex polysaccharides and a low molecular selectin antagonist, TBC1269, were used to
characterise and isolate the RSV receptor on a human epithelial cell line (Hep2 cells). The …