Tauopathies are neurodegenerative diseases characterized by accumulation of Tau
amyloids, and include Alzheimer disease and certain frontotemporal dementias. Trans-
neuronal propagation of amyloid mediated by extracellular Tau may underlie disease
progression. Consistent with this, active and passive vaccination studies in mouse models
reduce pathology, although by unknown mechanisms. We previously reported that
intracerebroventricular administration of three anti-Tau monoclonal antibodies (HJ8. 5, HJ9 …