Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase γ–deficient mice
M Takeda, W Ito, M Tanabe, S Ueki, H Kato… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Bronchial asthma is characterized by chronic airway inflammation caused
by inflammatory cells. Phosphoinositide 3-kinases (PI3Ks) are known to play a prominent
role in fundamental cellular responses of various inflammatory cells, including proliferation,
differentiation, and cell migration. PI3Ks therefore are expected to have therapeutic potential
for asthma. Although some investigations of the involvement between the pathogenesis of
asthma and PI3K have been performed, it is unknown whether PI3Kγ, a PI3K isoform, is …
by inflammatory cells. Phosphoinositide 3-kinases (PI3Ks) are known to play a prominent
role in fundamental cellular responses of various inflammatory cells, including proliferation,
differentiation, and cell migration. PI3Ks therefore are expected to have therapeutic potential
for asthma. Although some investigations of the involvement between the pathogenesis of
asthma and PI3K have been performed, it is unknown whether PI3Kγ, a PI3K isoform, is …