[HTML][HTML] Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids

M Almeida, LI Han, M Martin-Millan, LI Plotkin… - Journal of Biological …, 2007 - ASBMB
Both aging and loss of sex steroids have adverse effects on skeletal homeostasis, but
whether and how they may influence each others negative impact on bone remains
unknown. We report herein that both female and male C57BL/6 mice progressively lost
strength (as determined by load-to-failure measurements) and bone mineral density in the
spine and femur between the ages of 4 and 31 months. These changes were temporally
associated with decreased rate of remodeling as evidenced by decreased osteoblast and …