Spontaneous contractions evoke afferent nerve firing in mouse bladders with detrusor overactivity
CJ McCarthy, IV Zabbarova, PR Brumovsky… - The Journal of …, 2009 - Elsevier
PURPOSE: Afferent nerve firing has been linked to spontaneous bladder contractions in a
number of lower urinary tract pathologies and it may lead to urgency and incontinence.
Using optical mapping, single unit recording and tension measurements we investigated the
correlation between afferent nerve firing and spontaneous bladder contractions in spinal
cord transected mice. MATERIALS AND METHODS: Bladder-nerve preparations (bladder
sheets and the associated L6-S2 pelvic nerves) were dissected from normal and spinal cord …
number of lower urinary tract pathologies and it may lead to urgency and incontinence.
Using optical mapping, single unit recording and tension measurements we investigated the
correlation between afferent nerve firing and spontaneous bladder contractions in spinal
cord transected mice. MATERIALS AND METHODS: Bladder-nerve preparations (bladder
sheets and the associated L6-S2 pelvic nerves) were dissected from normal and spinal cord …