Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders
IF Mata, A Samii, SH Schneer, JW Roberts… - Archives of …, 2008 - jamanetwork.com
Background Mutations in the glucocerebrosidase (GBA) gene have been reported to modify
risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these
findings have not been consistently replicated, and most studies have had substantial
methodological shortcomings. Objective To better assess the role ofGBAvariants in altering
risk for Lewy body disorders. Design Case-control study. Setting Four movement disorder
clinics in the Seattle, Washington, area. Participants Seven hundred twenty-one patients …
risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these
findings have not been consistently replicated, and most studies have had substantial
methodological shortcomings. Objective To better assess the role ofGBAvariants in altering
risk for Lewy body disorders. Design Case-control study. Setting Four movement disorder
clinics in the Seattle, Washington, area. Participants Seven hundred twenty-one patients …
