[HTML][HTML] ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD
Background & Aims Identifying fibrosis in non-alcoholic fatty liver disease (NAFLD) is
essential to predict liver-related outcomes and guide treatment decisions. A protein-based
signature of fibrosis could serve as a valuable, non-invasive diagnostic tool. This study
sought to identify circulating proteins associated with fibrosis in NAFLD. Methods We used
aptamer-based proteomics to measure 4,783 proteins in 2 cohorts (Cohort A and B).
Targeted, quantitative assays coupling aptamer-based protein pull down and mass …
essential to predict liver-related outcomes and guide treatment decisions. A protein-based
signature of fibrosis could serve as a valuable, non-invasive diagnostic tool. This study
sought to identify circulating proteins associated with fibrosis in NAFLD. Methods We used
aptamer-based proteomics to measure 4,783 proteins in 2 cohorts (Cohort A and B).
Targeted, quantitative assays coupling aptamer-based protein pull down and mass …