[HTML][HTML] Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials
CT Trialists - The Lancet, 2010 - thelancet.com
Background Lowering of LDL cholesterol with standard statin regimens reduces the risk of
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and
efficacy of more intensive lowering of LDL cholesterol with statin therapy. Methods We
undertook meta-analyses of individual participant data from randomised trials involving at
least 1000 participants and at least 2 years' treatment duration of more versus less intensive
statin regimens (five trials; 39 612 individuals; median follow-up 5· 1 years) and of statin …
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and
efficacy of more intensive lowering of LDL cholesterol with statin therapy. Methods We
undertook meta-analyses of individual participant data from randomised trials involving at
least 1000 participants and at least 2 years' treatment duration of more versus less intensive
statin regimens (five trials; 39 612 individuals; median follow-up 5· 1 years) and of statin …
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.
C Baigent, L Blackwell, J Emberson… - Lancet (London …, 2010 - europepmc.org
Background Lowering of LDL cholesterol with standard statin regimens reduces the risk of
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and
efficacy of more intensive lowering of LDL cholesterol with statin therapy. Methods We
undertook meta-analyses of individual participant data from randomised trials involving at
least 1000 participants and at least 2 years' treatment duration of more versus less intensive
statin regimens (five trials; 39 612 individuals; median follow-up 5· 1 years) and of statin …
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and
efficacy of more intensive lowering of LDL cholesterol with statin therapy. Methods We
undertook meta-analyses of individual participant data from randomised trials involving at
least 1000 participants and at least 2 years' treatment duration of more versus less intensive
statin regimens (five trials; 39 612 individuals; median follow-up 5· 1 years) and of statin …
