[HTML][HTML] Identification of a Novel Epitope in the Thyroid-stimulating Hormone Receptor Ectodomain Acting as Intramolecular Signaling Interface*[boxs]
G Kleinau, H Jäschke, S Neumann, J Lättig… - Journal of Biological …, 2004 - ASBMB
Glycoprotein hormone receptors (GPHRs) differ from the other seven transmembrane
receptors mainly through a complex activation mechanism that requires the binding of a
large hormone toward a large N-terminal ectodomain. The intramolecular mechanism of the
signal transduction to the serpentine domain upon hormone binding at the ectodomain is not
understood. To identify determinants at the GPHR ectodomain that may be involved in signal
transduction, we first searched for homologous structural features. Based on high sequence …
receptors mainly through a complex activation mechanism that requires the binding of a
large hormone toward a large N-terminal ectodomain. The intramolecular mechanism of the
signal transduction to the serpentine domain upon hormone binding at the ectodomain is not
understood. To identify determinants at the GPHR ectodomain that may be involved in signal
transduction, we first searched for homologous structural features. Based on high sequence …
