[HTML][HTML] Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis
LJ Dixon, M Berk, S Thapaliya, BG Papouchado… - Laboratory …, 2012 - Elsevier
Non-alcoholic steatohepatitis (NASH) is typically associated with pro-apoptotic caspase
activation. A potential role for pro-inflammatory caspases remains incompletely understood.
Our aims were to examine a potential role of caspase-1 in the development of liver damage
and fibrosis in NASH. C57BL/6 wild type (WT) developed marked steatohepatitis, activation,
fibrosis and increased hepatic caspase-1 and interleukin-1β expression when placed on the
methionine-and choline-deficient (MCD) diet. Marked caspase-1 activation was detected in …
activation. A potential role for pro-inflammatory caspases remains incompletely understood.
Our aims were to examine a potential role of caspase-1 in the development of liver damage
and fibrosis in NASH. C57BL/6 wild type (WT) developed marked steatohepatitis, activation,
fibrosis and increased hepatic caspase-1 and interleukin-1β expression when placed on the
methionine-and choline-deficient (MCD) diet. Marked caspase-1 activation was detected in …