Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis
G Szabo, A Iracheta-Vellve - Clinics and research in hepatology and …, 2015 - Elsevier
Upregulation of the inflammatory cascade is a major element both in the progression of
steatohepatitis to severe alcoholic hepatitis as well as in the progression of NASH to
advanced NASH with fibrosis. The mechanisms underpinning these changes are only
partially understood. Activation of the inflammatory cascade requires multiple stimuli and in
this report, we discuss the role of inflammasomes that activate IL-1β as well as the sterile
and pathogen-derived danger signals that results in inflammasome activation and …
steatohepatitis to severe alcoholic hepatitis as well as in the progression of NASH to
advanced NASH with fibrosis. The mechanisms underpinning these changes are only
partially understood. Activation of the inflammatory cascade requires multiple stimuli and in
this report, we discuss the role of inflammasomes that activate IL-1β as well as the sterile
and pathogen-derived danger signals that results in inflammasome activation and …