The FXR-FGF19 Gut–Liver Axis as a Novel “Hepatostat”
MA Avila, A Moschetta - Gastroenterology, 2015 - gastrojournal.org
The liver possesses an extraordinary regenerative capacity that is triggered upon death of
parenchymal cells or after partial liver resection. This fundamental response likely evolved to
protect the organ and the organism from endogenous and exogenous toxins and thus
preserve systemic metabolic homeostasis. 1 A number of mediators involved in the onset
and termination of liver regeneration have been identified over the years, and these where
categorized by the late Nelson Fausto into 3 types of interconnected pathways known as the …
parenchymal cells or after partial liver resection. This fundamental response likely evolved to
protect the organ and the organism from endogenous and exogenous toxins and thus
preserve systemic metabolic homeostasis. 1 A number of mediators involved in the onset
and termination of liver regeneration have been identified over the years, and these where
categorized by the late Nelson Fausto into 3 types of interconnected pathways known as the …