[HTML][HTML] Programmed death ligand 1 intracellular interactions with STAT3 and focal adhesion protein Paxillin facilitate lymphatic endothelial cell remodeling
JB Schafer, ED Lucas, M Dzieciatkowska… - Journal of Biological …, 2022 - ASBMB
Lymphatic endothelial cells (LECs) comprise lymphatic capillaries and vessels that guide
immune cells to lymph nodes (LNs) and form the subcapsular sinus and cortical and
medullary lymphatic structures of the LN. During an active immune response, the lymphatics
remodel to accommodate the influx of immune cells from the tissue, but factors involved in
remodeling are unclear. Here, we determined that a TSS motif within the cytoplasmic
domain of programmed death ligand 1 (PD-L1), expressed by LECs in the LN, participates in …
immune cells to lymph nodes (LNs) and form the subcapsular sinus and cortical and
medullary lymphatic structures of the LN. During an active immune response, the lymphatics
remodel to accommodate the influx of immune cells from the tissue, but factors involved in
remodeling are unclear. Here, we determined that a TSS motif within the cytoplasmic
domain of programmed death ligand 1 (PD-L1), expressed by LECs in the LN, participates in …