The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid
SB Mason, X Lai, RL Bacallao… - PROTEOMICS …, 2009 - Wiley Online Library
PROTEOMICS–Clinical Applications, 2009•Wiley Online Library
Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the
development of numerous fluid‐filled cysts in the kidneys of patients. We recently published
our description of the proteome of renal cyst fluid in ADPKD. As a follow‐up experiment, we
hypothesized that the protein‐bound subfraction consists of molecules of mechanistic or
diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified
44 distinct proteins in human cyst fluid.
development of numerous fluid‐filled cysts in the kidneys of patients. We recently published
our description of the proteome of renal cyst fluid in ADPKD. As a follow‐up experiment, we
hypothesized that the protein‐bound subfraction consists of molecules of mechanistic or
diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified
44 distinct proteins in human cyst fluid.
Abstract
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid‐filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow‐up experiment, we hypothesized that the protein‐bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.
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