[HTML][HTML] MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: relevance of GNbAC1 in multiple sclerosis treatment
Multiple sclerosis associated retrovirus envelope protein (MSRV-Env) was repeatedly
detected in brain lesions and blood of multiple sclerosis (MS) patients. We performed the
first pharmacological characterisation of MSRV-Env on recombinant and native human
TLR4. MSRV-Env is a full and highly potent TLR4 agonist of endogenous origin. MSRV-Env
induces TLR4-dependent pro-inflammatory stimulation of immune cells in vitro and in vivo,
and impairs oligodendrocytes precursor cells differentiation to myelinating oligodendrocytes …
detected in brain lesions and blood of multiple sclerosis (MS) patients. We performed the
first pharmacological characterisation of MSRV-Env on recombinant and native human
TLR4. MSRV-Env is a full and highly potent TLR4 agonist of endogenous origin. MSRV-Env
induces TLR4-dependent pro-inflammatory stimulation of immune cells in vitro and in vivo,
and impairs oligodendrocytes precursor cells differentiation to myelinating oligodendrocytes …