Inflammation and metabolic disorders

GS Hotamisligil - Nature, 2006 - nature.com
Nature, 2006nature.com
Metabolic and immune systems are among the most fundamental requirements for survival.
Many metabolic and immune response pathways or nutrient-and pathogen-sensing systems
have been evolutionarily conserved throughout species. As a result, immune response and
metabolic regulation are highly integrated and the proper function of each is dependent on
the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of
which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 …
Abstract
Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.
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