[HTML][HTML] Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

XJ Qi, GM Wildey, PH Howe - Journal of Biological Chemistry, 2006 - ASBMB
Bim, the Bcl-2 interacting mediator of cell death, is a member of the BH3-only family of pro-
apoptotic proteins. Recent studies have demonstrated that the apoptotic activity of Bim can
be regulated through a post-translational mechanism whereby ERK phosphorylation serves
as a signal for Bim ubiquitination and proteasomal degradation. In this report, we
investigated the signaling pathways leading to Bim phosphorylation in Ba/F3 cells, an
interleukin-3 (IL-3)-dependent B-cell line. IL-3 stimulation induced phosphorylation of Bim …