[HTML][HTML] Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim
DA Hildeman, Y Zhu, TC Mitchell, P Bouillet, A Strasser… - Immunity, 2002 - cell.com
DA Hildeman, Y Zhu, TC Mitchell, P Bouillet, A Strasser, J Kappler, P Marrack
Immunity, 2002•cell.comAt the end of the T cell response, the majority of the activated T cells die. We activated Vβ8+
T cells with staphylococcal enterotoxin B (SEB) in vivo and monitored the expansion and
deletion of Vβ8+ T cells. We found that, in response to SEB, activated T cells died in vivo in
the absence of Fas or TNF-R signaling but not when they overexpressed human Bcl-2. We
also found that Vβ8+ T cells from Bim-deficient mice are resistant to SEB-induced deletion.
While Bim levels did not change, endogenous Bcl-2 levels within Vβ8+ T cells decrease …
T cells with staphylococcal enterotoxin B (SEB) in vivo and monitored the expansion and
deletion of Vβ8+ T cells. We found that, in response to SEB, activated T cells died in vivo in
the absence of Fas or TNF-R signaling but not when they overexpressed human Bcl-2. We
also found that Vβ8+ T cells from Bim-deficient mice are resistant to SEB-induced deletion.
While Bim levels did not change, endogenous Bcl-2 levels within Vβ8+ T cells decrease …
Abstract
At the end of the T cell response, the majority of the activated T cells die. We activated Vβ8+ T cells with staphylococcal enterotoxin B (SEB) in vivo and monitored the expansion and deletion of Vβ8+ T cells. We found that, in response to SEB, activated T cells died in vivo in the absence of Fas or TNF-R signaling but not when they overexpressed human Bcl-2. We also found that Vβ8+ T cells from Bim-deficient mice are resistant to SEB-induced deletion. While Bim levels did not change, endogenous Bcl-2 levels within Vβ8+ T cells decrease following SEB injection. Thus, the death of superantigen-stimulated T cells in vivo is mediated by Bim and may be modulated by a decrease in Bcl-2.
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