Introduction: Vestibular sensory hair cells are precisely orientated according to planar cell
polarity (PCP) and are key to enable mechanic-electrical transduction and normal vestibular
function. PCP is found on different scales in the vestibular organs, ranging from correct hair
bundle orientation, coordination of hair cell orientation with neighboring hair cells, and
orientation around the striola in otolithic organs. Celsr1 is a PCP protein and a Celsr1 KO
mouse model showed hair cell disorganization in all vestibular organs, especially in the …

Methods: Vestibular function was analyzed using non-invasive video-oculography.
Semicircular canal function was assessed during sinusoidal rotation and during angular
velocity steps. Otolithic function (mainly utricular) was assessed during off-vertical axis
rotation (OVAR) and during static and dynamic head tilts.