Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that plays a central role in
inflammation. Glomerular levels of TNF-alpha are elevated in human and experimental
glomerulonephritis. Glomerular cells produce and respond to TNF-alpha. One of the
mechanisms by which these cells respond to TNF-alpha is through generation of reactive
oxygen species. In this study, the effect of TNF-alpha on albumin permeability (P (albumin))
of isolated rat glomeruli and the possible mechanism of this effect were examined. Isolated …