De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease
Background IgG 4-related disease (IgG 4-RD) is a poorly understood, multiorgan, chronic
inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative
phlebitis, and accumulation of IgG 4-expressing plasma cells at disease sites. Objective The
role of B cells and IgG 4 antibodies in IgG 4-RD pathogenesis is not well defined. We
evaluated patients with IgG 4-RD for activated B cells in both disease lesions and peripheral
blood and investigated their role in disease pathogenesis. Methods B-cell populations from …
inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative
phlebitis, and accumulation of IgG 4-expressing plasma cells at disease sites. Objective The
role of B cells and IgG 4 antibodies in IgG 4-RD pathogenesis is not well defined. We
evaluated patients with IgG 4-RD for activated B cells in both disease lesions and peripheral
blood and investigated their role in disease pathogenesis. Methods B-cell populations from …