Transplantation of telomerase/myocardin-co-expressing mesenchymal cells in the mouse promotes myocardial revascularization and tissue repair
R Madonna, D Pieragostino, C Rossi, S Guarnieri… - Vascular …, 2020 - Elsevier
Aim Cell therapies are hampered by poor survival and growth of grafts. We tested whether
forced co-expression of telomerase reverse transcriptase (TERT) and myocardin (MYOCD)
improves post-infarct revascularization and tissue repair by adipose tissue-derived
mesenchymal stromal cells (AT-MSCs). Methods and results We transplanted AT-MSCs
overexpressing MYOCD and TERT in a murine model of acute myocardial infarction (AMI).
We characterized paracrine effects of AT-MSCs. When transplanted into infarcted hearts of …
forced co-expression of telomerase reverse transcriptase (TERT) and myocardin (MYOCD)
improves post-infarct revascularization and tissue repair by adipose tissue-derived
mesenchymal stromal cells (AT-MSCs). Methods and results We transplanted AT-MSCs
overexpressing MYOCD and TERT in a murine model of acute myocardial infarction (AMI).
We characterized paracrine effects of AT-MSCs. When transplanted into infarcted hearts of …
