Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions
and cellular processes. Activation of Notch signaling is normally tightly controlled by direct
interactions with ligand-expressing cells, and dysregulated Notch signaling is associated
with developmental abnormalities and cancer. While canonical Notch ligands are
responsible for the majority of Notch signaling, a diverse group of structurally unrelated …