[HTML][HTML] Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice
Cardiac hypertrophy and dilation are mediated by neuroendocrine factors and/or mitogens
as well as through internal stretch-and stress-sensitive signaling pathways, which in turn
transduce alterations in cardiac gene expression through specific signaling pathways. The
transcription factor family known as myocyte enhancer factor 2 (MEF2) has been implicated
as a signal-responsive mediator of the cardiac transcriptional program. For example, known
hypertrophic signaling pathways that utilize calcineurin, calmodulin-dependent protein …
as well as through internal stretch-and stress-sensitive signaling pathways, which in turn
transduce alterations in cardiac gene expression through specific signaling pathways. The
transcription factor family known as myocyte enhancer factor 2 (MEF2) has been implicated
as a signal-responsive mediator of the cardiac transcriptional program. For example, known
hypertrophic signaling pathways that utilize calcineurin, calmodulin-dependent protein …