[HTML][HTML] Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D
TI Slepak, KA Webster, J Zang, H Prentice… - Journal of Biological …, 2001 - ASBMB
The transcriptional integrator p300 regulates gene expression by interaction with sequence-
specific DNA-binding proteins and local remodeling of chromatin. p300 is required for
cardiac-specific gene transcription, but the molecular basis of this requirement is unknown.
Here we report that the MADS (MCM-1, agamous, deficiens, serum response factor) box
transcription factor myocyte enhancer factor-2D (MEF-2D) acts as the principal conduit for
cardiac transcriptional activation by p300. p300 activation of the native 2130-base pair …
specific DNA-binding proteins and local remodeling of chromatin. p300 is required for
cardiac-specific gene transcription, but the molecular basis of this requirement is unknown.
Here we report that the MADS (MCM-1, agamous, deficiens, serum response factor) box
transcription factor myocyte enhancer factor-2D (MEF-2D) acts as the principal conduit for
cardiac transcriptional activation by p300. p300 activation of the native 2130-base pair …