Conserved and divergent features of human and mouse kidney organogenesis

NO Lindström, JA McMahon, J Guo, T Tran… - Journal of the …, 2018 - journals.lww.com
Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney
development initiates around 4 weeks of gestation and ends around 34–37 weeks of
gestation. Over this period, a reiterative inductive process establishes the nephron
complement. Studies have provided insightful anatomic descriptions of human kidney
development, but the limited histologic views are not readily accessible to a broad audience …