Renal ischemia-reperfusion injury is mediated by a complex cascade of events, including
the immune response, that occur secondary to injury to renal epithelial cells. We tested the
hypothesis that heme oxygenase-1 (HO-1) expression, which is protective in ischemia-
reperfusion injury, regulates trafficking of myeloid-derived immune cells in the kidney. Age-
matched male wild-type (HO-1+/+), HO-1–knockout (HO-1−/−), and humanized HO-1–
overexpressing (HBAC) mice underwent bilateral renal ischemia for 10 minutes. Ischemia …