Chapter three-ubiquitination and protein turnover of G-protein-coupled receptor kinases in GPCR signaling and cellular regulation

P Penela - Progress in molecular biology and translational …, 2016 - Elsevier
G-protein-coupled receptors (GPCRs) are responsible for regulating a wide variety of
physiological processes, and distinct mechanisms for GPCR inactivation exist to guarantee
correct receptor functionality. One of the widely used mechanisms is receptor
phosphorylation by specific G-protein-coupled receptor kinases (GRKs), leading to
uncoupling from G proteins (desensitization) and receptor internalization. GRKs and β-
arrestins also participate in the assembly of receptor-associated multimolecular complexes …