Increased p53 protein expression in human failing myocardium
H Song, JV Conte Jr, AH Foster, JS McLaughlin… - The Journal of heart and …, 1999 - Elsevier
BACKGROUND: The p53 gene is a tumor-suppressor gene which involves apoptosis and
cell-cycle arrest under certain stress stimulate. However, the status of the p53 gene
expression in human myocardium in congestive heart failure (CHF) remains unclear.
Therefore, the current study was designed to investigate the expression of the p53 protein in
human myocardium in normal subjects and in patients with severe CHF. METHODS: Human
ventricular cardiac tissue was obtained from 7 normal subjects and 7 end-stage CHF …
cell-cycle arrest under certain stress stimulate. However, the status of the p53 gene
expression in human myocardium in congestive heart failure (CHF) remains unclear.
Therefore, the current study was designed to investigate the expression of the p53 protein in
human myocardium in normal subjects and in patients with severe CHF. METHODS: Human
ventricular cardiac tissue was obtained from 7 normal subjects and 7 end-stage CHF …
