Insights from in vivo modification of adrenergic receptor gene expression
DK Rohrer, BK Kobilka - Annual review of pharmacology and …, 1998 - annualreviews.org
▪ Abstract Adrenergic receptors are key targets within the autonomic nervous system,
regulating a wide variety of physiological processes. The ability to modify adrenergic
receptor expression patterns in vivo has added a powerful new tool to the functional analysis
of these receptors. Modification of adrenergic receptor gene expression by overexpression,
genetic ablation, or site-specific mutation has added new insight to models of receptor
coupling behavior, pharmacology, and subtype-specific physiological function. This review …
regulating a wide variety of physiological processes. The ability to modify adrenergic
receptor expression patterns in vivo has added a powerful new tool to the functional analysis
of these receptors. Modification of adrenergic receptor gene expression by overexpression,
genetic ablation, or site-specific mutation has added new insight to models of receptor
coupling behavior, pharmacology, and subtype-specific physiological function. This review …
