[HTML][HTML] Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway
P Penela, A Ruiz-Gómez, JG Castaño… - Journal of Biological …, 1998 - ASBMB
GRK2 is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family and
has been shown to play a key role in determining the desensitization and resensitization
patterns of a variety of G protein-coupled receptors. In this report, we show that GRK2 is
actively degraded by the proteasome proteolytic pathway, unveiling a new mechanism for
the rapid regulation of its expression levels. Interestingly, activation of β 2-adrenergic
receptors (β 2 AR) markedly increases GRK2 ubiquitination and degradation through the …
has been shown to play a key role in determining the desensitization and resensitization
patterns of a variety of G protein-coupled receptors. In this report, we show that GRK2 is
actively degraded by the proteasome proteolytic pathway, unveiling a new mechanism for
the rapid regulation of its expression levels. Interestingly, activation of β 2-adrenergic
receptors (β 2 AR) markedly increases GRK2 ubiquitination and degradation through the …