Sjögren's syndrome: an old tale with a new twist
BH Lee, MA Tudares, CQ Nguyen - Archivum immunologiae et therapiae …, 2009 - Springer
BH Lee, MA Tudares, CQ Nguyen
Archivum immunologiae et therapiae experimentalis, 2009•SpringerSjögren's syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva
and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of
the disease remains elusive, perhaps due to the multiple triggers of the disease. However,
substantial advances have been made in attempting to resolve the complexity of SjS using
both animal models and human subjects. The primary objectives of this review are to
provide a better understanding of the disease processes with major emphasis on the use of …
and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of
the disease remains elusive, perhaps due to the multiple triggers of the disease. However,
substantial advances have been made in attempting to resolve the complexity of SjS using
both animal models and human subjects. The primary objectives of this review are to
provide a better understanding of the disease processes with major emphasis on the use of …
Abstract
Sjögren’s syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of the disease remains elusive, perhaps due to the multiple triggers of the disease. However, substantial advances have been made in attempting to resolve the complexity of SjS using both animal models and human subjects. The primary objectives of this review are to provide a better understanding of the disease processes with major emphasis on the use of mouse models, how genetic predisposition plays a role in the natural history of the disease, as well as a presentation of new findings pertaining to the role of TH1, TH2, and TH17 cells in the pathogenesis of SjS.
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