Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients
T Wang, LA Green, SK Gupta, T Amet… - AIDS Research and …, 2015 - liebertpub.com
AIDS Research and Human Retroviruses, 2015•liebertpub.com
We report here the novel finding that HIV-negative factor (Nef) protein is present in
considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-
infected patients not on antiretroviral therapy (ART) and also in patients receiving
virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive
PBMCs constitute predominantly uninfected bystander cells. These results may explain
systemic pathology in HIV patients, even in those receiving ART.
considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-
infected patients not on antiretroviral therapy (ART) and also in patients receiving
virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive
PBMCs constitute predominantly uninfected bystander cells. These results may explain
systemic pathology in HIV patients, even in those receiving ART.
Abstract
We report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.
Mary Ann Liebert