Podoplanin expression in wound and hyperproliferative psoriatic epidermis: regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

M Honma, M Minami-Hori, H Takahashi… - Journal of dermatological …, 2012 - Elsevier
BACKGROUND: Podoplanin (PDPN)/T1α/aggrus/PA2. 26 antigen, a transmembranous
glycoprotein, is a well-known lymphatic endothelial marker. Recent evidence indicates that
PDPN is also expressed in keratinocytes especially of sebaceous glands. OBJECTIVE: To
verify expression-pattern and the regulatory mechanism of PDPN in human epidermal
keratinocytes. METHODS: PDPN-expression pattern was analyzed in normal and psoriatic
epidermis by immunostaining. The regulatory mechanism of PDPN-expression of …