[PDF][PDF] Altered myocardial calcium cycling and energetics in heart failure—a rational approach for disease treatment

PA Gorski, DK Ceholski, RJ Hajjar - Cell metabolism, 2015 - cell.com
PA Gorski, DK Ceholski, RJ Hajjar
Cell metabolism, 2015cell.com
Cardiomyocyte function depends on coordinated movements of calcium into and out of the
cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling
proteins and abnormal energy metabolism are features of heart failure. Recent discoveries
have led to gene-based therapies targeting calcium-transporting or-binding proteins, such
as the cardiac sarco (endo) plasmic reticulum calcium ATPase (SERCA2a), leading to
improvements in calcium homeostasis and excitation-contraction coupling. Here we review …
Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling proteins and abnormal energy metabolism are features of heart failure. Recent discoveries have led to gene-based therapies targeting calcium-transporting or -binding proteins, such as the cardiac sarco(endo)plasmic reticulum calcium ATPase (SERCA2a), leading to improvements in calcium homeostasis and excitation-contraction coupling. Here we review impaired calcium cycling and energetics in heart failure, assessing their roles from both a mutually exclusive and interdependent viewpoint, and discuss therapies that may improve the failing myocardium.
cell.com