[HTML][HTML] The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions
J Vanoevelen, L Dode, K Van Baelen… - Journal of biological …, 2005 - ASBMB
Accumulation of Ca 2+ into the Golgi apparatus is mediated by sarco (endo) plasmic
reticulum Ca 2+-ATPases (SERCAs) and by secretory pathway Ca 2+-ATPases (SPCAs).
Mammals and birds express in addition to the housekeeping SPCA1 (human gene name
ATP2C1, cytogenetic position 3q22. 1) a homologous SPCA2 isoform (human gene name
ATP2C2, cytogenetic position 16q24. 1). We show here that both genes present an identical
exon/intron layout. We confirmed that hSPCA2 has the ability to transport Ca 2+ …
reticulum Ca 2+-ATPases (SERCAs) and by secretory pathway Ca 2+-ATPases (SPCAs).
Mammals and birds express in addition to the housekeeping SPCA1 (human gene name
ATP2C1, cytogenetic position 3q22. 1) a homologous SPCA2 isoform (human gene name
ATP2C2, cytogenetic position 16q24. 1). We show here that both genes present an identical
exon/intron layout. We confirmed that hSPCA2 has the ability to transport Ca 2+ …
