[HTML][HTML] Clotrimazole inhibits the Ca2+-ATPase (SERCA) by interfering with Ca2+ binding and favoring the E2 conformation
G Bartolommei, F Tadini-Buoninsegni, S Hua… - Journal of biological …, 2006 - ASBMB
Clotrimazole (CLT) is an antimycotic imidazole derivative that is known to inhibit cytochrome
P-450, ergosterol biosynthesis and proliferation of cells in culture, and to interfere with
cellular Ca 2+ homeostasis. We found that CLT inhibits the Ca 2+-ATPase of rabbit fast-
twitch skeletal muscle (SERCA1), and we characterized in detail the effect of CLT on this
calcium transport ATPase. We used biochemical methods for characterization of the ATPase
and its partial reactions, and we also performed measurements of charge movements …
P-450, ergosterol biosynthesis and proliferation of cells in culture, and to interfere with
cellular Ca 2+ homeostasis. We found that CLT inhibits the Ca 2+-ATPase of rabbit fast-
twitch skeletal muscle (SERCA1), and we characterized in detail the effect of CLT on this
calcium transport ATPase. We used biochemical methods for characterization of the ATPase
and its partial reactions, and we also performed measurements of charge movements …