Increased expression of cardiac phosphatases in patients with end-stage heart failure

J Neumann, T Eschenhagen, LR Jones, B Linck… - Journal of molecular and …, 1997 - Elsevier
J Neumann, T Eschenhagen, LR Jones, B Linck, W Schmitz, H Scholz, N Zimmermann
Journal of molecular and cellular cardiology, 1997Elsevier
Type 1 phosphatase activity was increased in membrane vesicles from failing human
ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding
for type 1 phosphatase was enhanced by 37%. The present study provides evidence that
alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced
activity of phosphatases may be causally related to heart failure and/or may aggravate the
well known decreased cardiac responsiveness to positive inotropic agents in end-stage …
Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.
Elsevier