Encephalitogenic T cells in the B10. PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
DG Ando, J Clayton, D Kono, JL Urban, EE Sercarz - Cellular immunology, 1989 - Elsevier
T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of
murine EAE. We have developed a T cell line, BML-1, that (1) is reactive to the
encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP,(2) is IA u restricted, and (3)
induces relapsing EAE in B10. PL (H-2 u) mice. Measurement of the lymphokine profile of
BML-1 revealed secretion of IL-2, interferon-γ, and lymphotoxin but not IL-4. This profile is
consistent with the Th-1/DTH subtype. Coculture of BML-1 with MBP-primed B cells shows …
murine EAE. We have developed a T cell line, BML-1, that (1) is reactive to the
encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP,(2) is IA u restricted, and (3)
induces relapsing EAE in B10. PL (H-2 u) mice. Measurement of the lymphokine profile of
BML-1 revealed secretion of IL-2, interferon-γ, and lymphotoxin but not IL-4. This profile is
consistent with the Th-1/DTH subtype. Coculture of BML-1 with MBP-primed B cells shows …