The nuclear pore complex function of Sec13 protein is required for cell survival during retinal development
Sec13 is a dual function protein, being a core component of both the COPII coat, which
mediates protein trafficking from the endoplasmic reticulum to the Golgi apparatus, and the
nuclear pore complex (NPC), which facilitates nucleo-cytoplasmic traffic. Here, we present a
genetic model to differentiate the roles of these two functions of Sec13 in vivo. We report that
sec13 sq198 mutant embryos develop small eyes that exhibit disrupted retinal lamination
and that the mutant retina contains an excessive number of apoptotic cells. Surprisingly, we …
mediates protein trafficking from the endoplasmic reticulum to the Golgi apparatus, and the
nuclear pore complex (NPC), which facilitates nucleo-cytoplasmic traffic. Here, we present a
genetic model to differentiate the roles of these two functions of Sec13 in vivo. We report that
sec13 sq198 mutant embryos develop small eyes that exhibit disrupted retinal lamination
and that the mutant retina contains an excessive number of apoptotic cells. Surprisingly, we …
