α‐synuclein in the inner retina in parkinson disease
I Bodis‐Wollner, PB Kozlowski, S Glazman… - Annals of …, 2014 - Wiley Online Library
I Bodis‐Wollner, PB Kozlowski, S Glazman, S Miri
Annals of neurology, 2014•Wiley Online LibraryBehavioral, electrophysiological, and imaging data reveal impaired visual processing and
altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We
report the presence of misfolded α‐synuclein in the retina, not hitherto shown, in discrete
retinal neurons within the inner retina. They demonstrate the histopathology that may
underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the
histological localization of α‐synuclein gives clues to the nonsynaptic mode of α‐synuclein …
altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We
report the presence of misfolded α‐synuclein in the retina, not hitherto shown, in discrete
retinal neurons within the inner retina. They demonstrate the histopathology that may
underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the
histological localization of α‐synuclein gives clues to the nonsynaptic mode of α‐synuclein …
Behavioral, electrophysiological, and imaging data reveal impaired visual processing and altered retinal morphology in Parkinson disease. Are visual changes epiphenomena? We report the presence of misfolded α‐synuclein in the retina, not hitherto shown, in discrete retinal neurons within the inner retina. They demonstrate the histopathology that may underlie impaired vision and retinal remodeling in Parkinson disease. Furthermore, the histological localization of α‐synuclein gives clues to the nonsynaptic mode of α‐synuclein propagation. ANN NEUROL 2014;75:964–966
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