Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin
R Parthasarathy, KM Chow, Z Derafshi… - Experimental eye …, 2015 - Elsevier
Amyloid-beta (Aβ) is a group of aggregation-prone, 38-to 43-amino acid peptides generated
in the eye and other organs. Numerous studies suggest that the excessive build-up of low-
molecular-weight soluble oligomers of Aβ plays a role in the progression of Alzheimer's
disease and other brain degenerative diseases. Recent studies raise the hypothesis that
excessive Aβ levels may contribute also to certain retinal degenerative diseases. These
findings, together with evidence that a major portion of Aβ is released as monomer into the …
in the eye and other organs. Numerous studies suggest that the excessive build-up of low-
molecular-weight soluble oligomers of Aβ plays a role in the progression of Alzheimer's
disease and other brain degenerative diseases. Recent studies raise the hypothesis that
excessive Aβ levels may contribute also to certain retinal degenerative diseases. These
findings, together with evidence that a major portion of Aβ is released as monomer into the …
