Neuroprotective effect of memantine on the retinal ganglion cells of APPswe/PS1ΔE9 mice and its immunomodulatory mechanisms
L Gao, X Chen, Y Tang, J Zhao, Q Li, X Fan… - Experimental Eye …, 2015 - Elsevier
Besides the cognitive impairment and degeneration in the brain, vision dysfunction and
retina damage are always prevalent in patients with Alzheimer's disease (AD). The
uncompetitive antagonist of the N-methyl-d-aspartate receptor, memantine (MEM), has been
proven to improve the cognition of patients with AD. However, limited information exists
regarding the mechanism of neurodegeneration and the possible neuroprotective
mechanisms of MEM on the retinas of patients with AD. In the present study, by using …
retina damage are always prevalent in patients with Alzheimer's disease (AD). The
uncompetitive antagonist of the N-methyl-d-aspartate receptor, memantine (MEM), has been
proven to improve the cognition of patients with AD. However, limited information exists
regarding the mechanism of neurodegeneration and the possible neuroprotective
mechanisms of MEM on the retinas of patients with AD. In the present study, by using …