[HTML][HTML] Retinal microvascular network attenuation in Alzheimer's disease
MA Williams, AJ McGowan, CR Cardwell… - Alzheimer's & Dementia …, 2015 - Elsevier
MA Williams, AJ McGowan, CR Cardwell, CY Cheung, D Craig, P Passmore, G Silvestri…
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015•ElsevierIntroduction Cerebral small-vessel disease has been implicated in the development of
Alzheimer's disease (AD). The retinal microvasculature enables the noninvasive
visualization and evaluation of the systemic microcirculation. We evaluated retinal
microvascular parameters in a case-control study of AD patients and cognitively normal
controls. Methods Retinal images were computationally analyzed and quantitative retinal
parameters (caliber, fractal dimension, tortuosity, and bifurcation) measured. Regression …
Alzheimer's disease (AD). The retinal microvasculature enables the noninvasive
visualization and evaluation of the systemic microcirculation. We evaluated retinal
microvascular parameters in a case-control study of AD patients and cognitively normal
controls. Methods Retinal images were computationally analyzed and quantitative retinal
parameters (caliber, fractal dimension, tortuosity, and bifurcation) measured. Regression …
Introduction
Cerebral small-vessel disease has been implicated in the development of Alzheimer's disease (AD). The retinal microvasculature enables the noninvasive visualization and evaluation of the systemic microcirculation. We evaluated retinal microvascular parameters in a case-control study of AD patients and cognitively normal controls.
Methods
Retinal images were computationally analyzed and quantitative retinal parameters (caliber, fractal dimension, tortuosity, and bifurcation) measured. Regression models were used to compute odds ratios (OR) and confidence intervals (CI) for AD with adjustment for confounders.
Results
Retinal images were available in 213 AD participants and 294 cognitively normal controls. Persons with lower venular fractal dimension (OR per standard deviation [SD] increase, 0.77 [CI: 0.62–0.97]) and lower arteriolar tortuosity (OR per SD increase, 0.78 [CI: 0.63–0.97]) were more likely to have AD after appropriate adjustment.
Discussion
Patients with AD have a sparser retinal microvascular network and retinal microvascular variation may represent similar pathophysiological events within the cerebral microvasculature of patients with AD.
Elsevier